The Effects of Acute Hydrogen Sulfide Poisoning on Cytochrome P450 Isoforms Activity in Rats

Table 3

Pharmacokinetic parameters of six probe drugs after oral administration in acute hydrogen sulfide poisoning group and control group rats (mean ± SD, 𝑛=8).

Probe drugs	Parameters	AUC(0−𝑡)	AUC(0−∞)	MRT(0−𝑡)	MRT(0−∞)	𝑡1/2𝑧	𝑇max	𝐶𝐿𝑧/𝐹	𝑉𝑧/𝐹	𝐶max
	Unit	ng/mL*h	ng/mL*h	h	h	h	h	L/h/kg	L/kg	ng/mL
Bupropion	H2S	650.5 ± 208.4*	671.1 ± 225.9*	1.6 ± 0.2	1.8 ± 0.3	1.0 ± 0.3	0.2 ± 0.1	16.3 ± 5.1	21.6 ± 6.4	411.3 ± 113.3*
	Control	417.3 ± 192.6	427.3 ± 197.8	1.6 ± 0.2	1.7 ± 0.2	0.9 ± 0.4	0.2 ± 0.1	27.3 ± 10.9	33.9 ± 16.9	276.6 ± 72.3
Metoprolol	H2S	2182.9 ± 508.6**	2188.4 ± 510.5**	1.4 ± 0.2	1.4 ± 0.2	0.6 ± 0.1	0.3 ± 0.1	4.9 ± 1.5	3.9 ± 1.6	1235.7 ± 160.8**
	Control	1346.2 ± 593.6	1348.0 ± 593.2	1.3 ± 0.2	1.3 ± 0.2	0.5 ± 0.2	0.7 ± 0.5	9.5 ± 6.2	8.5 ± 8.9	810.8 ± 279.8
Midazolam	H2S	1703.7 ± 504.5	1715.4 ± 503.9	1.2 ± 0.1	1.3 ± 0.2	0.9 ± 0.5	0.2 ± 0.1	6.3 ± 2.0	9.0 ± 9.3	1253.0 ± 318.2
	Control	1811.1 ± 834.3	1819.9 ± 832.1	1.2 ± 0.1	1.2 ± 0.1	0.8 ± 0.3	0.2 ± 0.1	6.5 ± 2.8	8.5 ± 6.3	1343.6 ± 408.8
Phenacetin	H2S	1993.4 ± 667.3*	1998.1 ± 668.8*	0.7 ± 0.1	0.7 ± 0.2	0.4 ± 0.1*	0.3 ± 0.2	5.4 ± 1.6	2.9 ± 0.8	1847.7 ± 219.4**
	Control	1239.9 ± 675.8	1243.9 ± 677.7	0.7 ± 0.2	0.7 ± 0.2	0.6 ± 0.2	0.3 ± 0.2	11.1 ± 8.1	10.6 ± 12.1	1329.2 ± 397.6
Omeprazole	H2S	1826.6 ± 592.1	1830.1 ± 591.2	0.7 ± 0.1	0.7 ± 0.1	0.8 ± 0.3	0.1 ± 0.1	6.3 ± 3.0	7.7 ± 5.6	2248.6 ± 691.7
	Control	1919.3 ± 1013.1	1929.4 ± 1010.3	0.8 ± 0.1	0.8 ± 0.1	1.1 ± 0.3	0.2 ± 0.1	6.3 ± 2.6	10.2 ± 5.5	2357.7 ± 882.9
Tolbutamide	H2S	16139.1 ± 1941.3*	16240.0 ± 2149.2*	5.4 ± 1.6	5.7 ± 2.3	4.2 ± 2.4	1.9 ± 0.8	0.06 ± 0.01*	0.4 ± 0.2*	2216.5 ± 229.3*
	Control	11280.4 ± 3894.9	11290.6 ± 3906.9	5.6 ± 1.3	5.6 ± 1.3	3.9 ± 1.1	1.3 ± 0.8	0.10 ± 0.04	0.5 ± 0.2	1689.3 ± 503.0

Compared with the control group, *𝑃<0.05 and **𝑃<0.01.