Review Article
High-Throughput Analysis of Ovarian Granulosa Cell Transcriptome
Table 2
Gene expression profiling of human granulosa and cumulus cells.
| Type of cell | Assay | Gene profiles/outcome | Reference |
| Granulosa cells from aspirated follicular fluid | Microarray | FDX1, CYP19A1, CDC42, SERPINE2, and 3bHSD1, positively correlated with oocyte developmental competence | Hamel et al., 2008 [16] | Cumulus cells | Whole Human Genome Oligo Microarray 4x44K (Agilent Technologies) | RGS2, related to oocyte developmental competence | Feuerstein et al., 2012 [17] | Cumulus cells | Affymetrix HG-U133 Plus 2.0 array | BCL2L11, PCK1, and NFIB, significantly correlated with embryo potential | Assou et al., 2008 [18] | Cumulus cells from gonadotropin stimulated patients | Human Genome U133 Plus 2.0 microarrays | NPY1R, GM2A, GREM1 OSBPL6, STC2, and PTX3, correlated with embryo quality | Assou et al., 2013 [19] |
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