High-Throughput Analysis of Ovarian Granulosa Cell Transcriptome

Table 2

Gene expression profiling of human granulosa and cumulus cells.

Type of cell	Assay	Gene profiles/outcome	Reference
Granulosa cells from aspirated follicular fluid	Microarray	FDX1, CYP19A1, CDC42, SERPINE2, and  3bHSD1, positively correlated with oocyte developmental competence	Hamel et al., 2008 [16]
Cumulus cells	Whole Human Genome Oligo Microarray 4x44K (Agilent Technologies)	RGS2, related to oocyte developmental competence	Feuerstein et al., 2012 [17]
Cumulus cells	Affymetrix HG-U133 Plus 2.0 array	BCL2L11, PCK1, and  NFIB, significantly correlated with embryo potential	Assou et al., 2008 [18]
Cumulus cells from gonadotropin stimulated patients	Human Genome U133 Plus 2.0 microarrays	NPY1R, GM2A, GREM1 OSBPL6, STC2, and PTX3,  correlated with embryo quality	Assou et al., 2013 [19]