Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl Cellulose/BioC/Bone Morphogenic Protein-2 Hybrid Materials

Figure 4

Micro-CT images of (a) CMC/BioC, (b) CMC/BioC/BMP-2 (0.1 mg), and (c) CMC/BioC/BMP-2 (0.5 mg) at 4 weeks after implantation onto the tibial defects. (d) CMC/BioC, (e) CMC/BioC/BMP-2 (0.1 mg), and (f) CMC/BioC/BMP-2 (0.5 mg) at 8 weeks after implantation onto the tibial defects. The micro-CT images revealed slight mineralization at the defect site for both the CMC/BioC/BMP-2 (0.1 mg) and CMC/BioC/BMP-2 (0.5 mg) groups but no mineralization for the CMC/BioC group at 4 weeks. At 8 weeks, mineralization was much more extensive in the CMC/BioC/BMP-2 (0.5 mg) group than in the CMC/BioC or CMC/BioC/BMP-2 (0.1 mg) group at 8 weeks.