CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer

Figure 5

CCL18 treatment promotes tumor growth, expression pattern, and localization of Ki67, PCNA in RM-1 xenograft. Treat the mice with CCL18 for 4 weeks. (a) Tumor size. (b) The gain of weight. (g) Weight of each mouse was measured once a week (). (c) Tumor volumes were measured at 28th day and the results were used to plot the graphs (). In CCL18 treatment group, the expression levels of Ki67 ((d), ) and PCNA ((e), ) proteins were significantly higher than those in the control group. (f) CD31 staining and HE staining of control group. (g) CD31 staining and HE staining of CCL18 treatment group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)