Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy

Figure 2

Local V1aR overexpression in atrophic muscle enhances the regeneration process. (a) Cross-sections of mock (A), TNF- (B), V1aR- (C), and TNF+V1aR- (D) transfected TA were stained with H&E one week after electroporation. Scale bar = 50 μm. Original magnification 10x and insert magnification 20x. (b) Diagram showing the number of regenerating, nonregenerating, and total fibers per cross-sectional area. ^∗𝑃<0.05. (c) Morphometric analysis shows that in muscles overexpressing V1aR and TNF together the mean fiber cross sectional area (CSA) is bigger compared with samples overexpressing TNF alone. ^∗𝑃<0.05; ^∗∗𝑃<0.01 by Student’s 𝑡-test.

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