CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease

<table>Rotorod performance of control and experimental mice. Administration of MPTP significantly reduced the ability of animals to stay on the rotating rod (5, 10, and 15 rpm) when compared to control. Retention time was significantly improved as compared to MPTP group when animals were pretreated with CNB-001. Values are expressed as mean ± SD for six animals in each group. <svg height="17.825001" id="M6" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, <svg height="19.65" id="M7" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to MPTP.</table>

BioMed Research International

fig1

Figure 1

Figure 1: CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease 