CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease
Figure 8
Transmission electron micrographs of SN showing ultrastructural changes in control and experimental mice. All panels demonstrate SN neurons at 2000x. In control (a) and CNB-001 groups (d), increased mitochondrial population with prominent cristae were seen. In MPTP group (b), mitochondria showed abnormal structure with distorted cristae and the number of mitochondria was greatly reduced. In contrast CNB-001 treatment (c) dampened these apoptotic changes and improved mitochondrial morphology and population as compared to MPTP group.
