CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease

Table 1

In vivo antioxidant status of control and experimental mice.

Groups	Control	MPTP	CNB-001 + MPTP	CNB-001
TBARS (nmoles/g tissue)	0.86 ± 0.90^a	2.54 ± 0.20^b	1.79 ± 0.13^c	0.82 ± 0.09^a
GSH (mg/g of tissue)	9.31 ± 1.05^a	4.9 ± 0.39^b	7.92 ± 0.71^c	10.1 ± 1.02^a
GPx (U^A/mg protein)	9.6 ± 0.94^a	4.31 ± 0.32^b	7.36 ± 0.75^c	9.9 ± 0.90^a
SOD (U^B/mg protein)	1.32 ± 0.19^a	4.63 ± 0.50^b	3.36 ± 0.23^c	1.27 ± 0.21^a
Catalase (U^C/mg protein)	1.98 ± 0.17^a	3.96 ± 0.34^b	2.82 ± 0.14^c	1.94 ± 0.11^a

Values not sharing common superscript are significant with each other 𝑃<0.05.
^Anmol NADPH oxidized/minute/mg protein.
^BAmount of enzyme required to inhibit 50% of NBT reduction.
^Cnmol H₂O₂ consumed/minute/mg protein.