CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

Table 3

Survival analysis on CRC patients according to methylation of individual methylation marker and CIMP status in tumor tissue.

	Number of patients	Number of deaths	Overall survival (%)			Univariate		Multivariate
			3 y	5 y	7 y	HR and 95% CI		HR and 95% CI
MLH1
Unmethylation	211	76	71.00	56.00	48.00	Ref.		Ref.
Methylation	71	24	69.00	64.00	64.00	0.94 (0.59–1.48)	0.77	1.07 (0.66–1.74)	0.79
MGMT
Unmethylation	184	65	72.00	59.00	50.00	Ref.		Ref.
Methylation	98	35	68.00	56.00	56.00	1.02 (0.68–1.54)	0.93	1.05 (0.69–1.61)	0.81
p16
Unmethylation	226	79	72.00	60.00	53.00	Ref.		Ref.
Methylation	56	21	67.00	47.00	47.00	1.27 (0.78–2.05)	0.34	1.05 (0.64–1.73)	0.85
APC
Unmethylation	207	67	72.00	63.00	59.00	Ref.		Ref.
Methylation	75	33	67.00	44.00	34.00	1.46 (0.96–2.21)	0.08	1.61 (1.05–2.46)	0.03
MINT1
Unmethylation	223	76	73.00	59.00	51.00	Ref.		Ref.
Methylation	59	24	62.00	53.00	53.00	1.36 (0.86–2.16)	0.19	1.38 (0.85–2.24)	0.20
MINT31
Unmethylation	146	52	72.00	56.00	50.00	Ref.		Ref.
Methylation	136	48	69.00	59.00	54.00	1.04 (0.70–1.54)	0.84	1.01 (0.67–1.53)	0.96
RUNX3
Unmethylation	228	83	70.00	58.00	51.00	Ref.		Ref.
Methylation	54	17	73.00	55.00	55.00	0.90 (0.53–1.52)	0.69	1.14 (0.67–1.95)	0.63
CIMP status
CIMP-0	36	12	77.00	59.00	59.00	Ref.		Ref.
CIMP-L	209	70	72.00	61.00	54.00	0.99 (0.53–1.82)	0.96	0.95 (0.60–1.52)	0.84
CIMP-H	37	18	58.00	33.00	33.00	1.71 (0.82–3.55)	0.15	3.06 (1.19–7.89)	0.02
CIMP-H versus CIMP-L						1.78 (1.07–3.03)	0.03	1.97 (1.11–3.48)	0.02
CIMP-H versus CIMP-L; and CIMP-0						1.80 (1.08–3.00)	0.03	2.31 (1.02–5.24)	0.04

Multivariate analysis, adjusted for age at diagnosis, tumor stage, tumor differentiation, and tumor location.