Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease

Figure 1

The Hsp70 and Hsp90 chaperone cycle. Protein is recognized by the Hsp70/40 complex with CHIP. The HOP facilitates transfer of the protein from Hsp70/40 complex to Hsp90 complex. Cochaperone p23 binds to complex of HSP90 and client protein to refold the client protein. Then the folded protein, HSP90, and cochaperone p23 release from the complex. Hsp70, Hsp40, HSP90, AHA1, CHIP, and p23 are regenerated that could be participated in the next cycle of protein folding action.