Identification of Influenza A/H7N9 Virus Infection-Related Human Genes Based on Shortest Paths in a Virus-Human Protein Interaction Network

Figure 1

The flowchart of the method developed in this study to identify the Influenza A/H7N9 infection-related human genes. Target human proteins interacting with the Influenza A/H7N9 virus were obtained based on sharing GO terms. Shortest path proteins were calculated from the shortest paths between every pair of the target human proteins, by searching by the Dijkstra algorithm in the network constructed from STRING. Finally 20 shortest path proteins were screened out with betweenness >10,000, the related genes of which were considered as infection-related human genes.