Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers

Table 1

Effects of antiblastic drugs on heart.

Drugs	CHF*	ECG change	Bradycardia	Ischemia	Arrythmias	Myo/pericarditis	Hypotension	Hypertension
Anthracyclines	++	++			+	+
Trastuzumab	++
5-FU	+	+		++	+
Cisplatin		++		++				++
Bleomycin		+				+
Cyclophosphamide	+++	++				++
Methotrexate		+					+
Doxorubicin	+	+						+
Taxoids (paclitaxel)		++	+	+	++		+
Mitoxantrone					+		+
TKIs (sorafenib, sunitinib, etc.)	+++							++

∗CHF: congestive heart failure.