Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS
Table 3
Effect of BHE on lipid peroxidation (MDA), GSH, and antioxidant enzymes after 6 weeks of CCl4 intoxication in mice.
Animal groups
GSH (mole/g liver)
GPx (mole/min/g liver)
GR (mole/min/g liver)
GST (mole/min/g liver)
SOD (mole/min/g liver)
MDA (nmole/g liver)
Control
3.74 ± 0.32$
3.08 ± 0.29$
2.46 ± 0.23$
48.96 ± 4.87$
355.85 ± 7.26$
32.36 ± 3.26$
CCl4
2.10 ± 0.24*
1.64 ± 0.23*
1.57 ± 0.27$
20.85 ± 2.73*
236.56 ± 4.08*
64.37 ± 4.18*
BHE (500 mg/kg/day)
3.18 ± 0.24$ (+51%)
2.51 ± 0.24$* (+53%)
2.30 ± 0.27$ (+46%)
35.09 ± 2.47$* (+68%)
297.48 ± 4.86# (+26%)
39.03 ± 3.97$ (−39%)
BHE (1000 mg/kg/day)
3.69 ± 0.19$ (+76%)
3.00 ± 0.26$ (+83%)
2.37 ± 0.33$ (+51%)
41.91 ± 4.31$ (+101%)
(+37%)
31.32 ± 3.47$ (−51%)
Silymarin (500 mg/kg/day)
3.38 ± 0.28$ (+61%)
2.51 ± 0.30$* (+53%)
2.19 ± 0.36$ (+39%)
33.58 ± 4.21$* (+61%)
(+33%)
36.10 ± 2.39$ (−44%)
Data are expressed as the means ± SEM, (). The numbers in parentheses represent the percent change from the CCl4-intoxicated group. Values having different superscripts within the same column are significantly different at .
