Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy

Figure 2

Bioinformatic STRING analysis of the proteomic data from the label-free mass spectrometric study of the aged mdx heart. For the evaluation of protein-protein interactions of the mass spectrometrically identified proteins with a changed abundance in the dystrophic mdx heart [18], bioinformatic analysis was carried out with the publically available STRING (http:// http://string-db.org/; version 9.1) database of known and predicted protein interactions that include direct physical and indirect functional protein associations [19]. The interaction map of cardiac proteins with a changed abundance in the dystrophic mdx heart illustrates the enormous complexity of potential protein interactions, especially with respect to mitochondrial components.