Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract from Nigella sativa Seed in Rat Aorta: The Roles of Ca²⁺ and K⁺ Channels

Figure 2

Effect of cumulative concentrations of Nigella sativa seed extract (2, 4, 6, 8, 10, and 14 mg/mL) on PE precontracted rat aortic rings with endothelium (PE + E) and after pretreatment with L-NAME (10 μM) (PE + L-NAME) or indomethacin (10 μM) (PE + Indo). Data are expressed as mean ± S.E.M. (𝑛=8).