Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract from Nigella sativa Seed in Rat Aorta: The Roles of Ca²⁺ and K⁺ Channels

Figure 3

Effect of Nigella sativa seed extract at 14 mg/mL on the Ca²⁺-induced (0.01–10 mM) contraction of rat aortic rings without endothelium pretreated with PE (10⁻⁶ M) (a) or KCl (6×10⁻² M) (b). Data are expressed as mean ± S.E.M. (𝑛=8). ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 compared tocontrol.

(a)

(b)