Promoter Region Hypermethylation and mRNA Expression of MGMT and p16 Genes in Tissue and Blood Samples of Human Premalignant Oral Lesions and Oral Squamous Cell Carcinoma

Table 1

Mean age and sex of patients and their distribution according to exposure to risk factors.

Features	Control (𝑛=16)	PMOLs (𝑛=54)				OSCC (𝑛=76)
		LKP (𝑛=22)	LKPD (𝑛=11)	SMF (𝑛=13)	OLP (𝑛=8)
Age ± SD (Yrs)	29 ± 8.28	39 ± 13.59	34 ± 11	40 ± 13	34 ± 8	53 ± 12.97
Sex (M/F)	12/4	19/3	10/1	11/2	7/1	69/7
Tobacco consumers	9 (56%)	20 (91%)	10 (91%)	13 (100%)	8 (100%)	59 (78%)
Alcohol consumers	5 (31%)	6 (27%)	3 (27%)	—^#	3 (38%)	19 (25%)
Pan masala users	3 (19%)	10 (45%)	7 (64%)	3 (23%)	5 (63%)	23 (30%)
Bidi smokers	10 (62.5%)	15 (68%)	7 (64%)	8 (62%)	5 (62.5%)	43 (57%)

M: male, F: female; SD: standard deviation. PMOLs: premalignant oral lesions; LKP and LKPD: leukoplakia with and without dysplasia; SMF: submucosal fibrosis; OLP: oral lichen planus.
^#Out of 13 SMF patients none of the patients was found to have the habit of alcohol drinking.