Research Article

Development and Evaluation of an Open-Source Software Package “CGITA” for Quantifying Tumor Heterogeneity with Molecular Images

Table 1

Summary of the currently supported heterogeneity indices of CGITA.

Parent matrixFeature measure

Cooccurrence matrix [17]Second angular moment, contrast, entropy, homogeneity, dissimilarity, inverse difference moment
Voxel-alignment matrix [19]Short-run emphasis, long-run emphasis, intensity variability, run-length variability, run percentage, low-intensity run emphasis, high-intensity run emphasis, low-intensity short-run emphasis, high-intensity short-run emphasis, low-intensity long-run emphasis, high-intensity long-run emphasis
Neighborhood intensity difference matrix [20]Coarseness, contrast, busyness, complexity, strength
Intensity size-zone matrix [21]Short-zone emphasis, large-zone emphasis, intensity variability, size-zone variability, zone percentage, low-intensity zone emphasis, high-intensity zone emphasis, low-intensity short-zone emphasis, high-intensity short-zone emphasis, low-intensity large-zone emphasis, high-intensity large-zone emphasis
Normalized cooccurrence matrix [17]Second angular moment, contrast, entropy, homogeneity, inverse difference moment, dissimilarity, correlation
Voxel statistics Minimum SUV, maximum SUV, mean SUV, SUV variance, SUV SD, SUV skewness, SUV kurtosis, SUV skewness (bias corrected), SUV kurtosis (bias corrected), TLG, tumor volume, entropy, SULpeak
Texture spectrum [15]Max spectrum, Black-white symmetry
Texture feature coding [16]Coarseness, homogeneity, mean convergence
Texture feature coding cooccurrence matrix [16]Second angular moment, contrast, entropy, homogeneity, intensity, inverse difference moment, correlation, variance, code similarity
Neighborhood gray-level dependence [22]Small-number emphasis, large-number emphasis, number nonuniformity, second moment, entropy