Evaluation of Bax and Bak Gene Mutations and Expression in Breast Cancer

Table 1

The coloration between Bak expression and clinical factors.

Factors	Bak expression
	Number of tumors^a	Mean expression level	𝑃 *	𝑃 **
Normal tissue	4	0.350	0.001 𝑃***	0.077; 0.019
Tumor < 0.35	5	0.201
Tumor > 0.35	8	0.598
Grade
2	16	0.458	0.185	0.427
3+ high	3	0.672		0.006
T stage
T1	3	0.355	0.306 𝑃***	0.953
T2	7	0.462		0.084
T3	3	0.407		0.762
T4	6	0.644		0.061
L.N.
N0	6	0.448	0.642 𝑃***	0.45; 0.520; 0.026
N1	6	0.478
N2	7	0.575
N3	1	0.277
Histopathology
Invasive duct  carcinoma	17	0.479	0.557	0.323
Lobular + other	3	0.576		0.157
ER
Positive	9	0.562	0.520	0.195
Negative	6	0.464		0.2
PR
Positive	7	0.544	0.98	0.29
Negative	7	0.547		0.1

aSome cases are omitted because of missing values.
𝑃^∗:  Student’s 𝑡-test used to determine the significance of the Bak expression among subgroups. Statistical significance was at 𝑃≤0.05.
𝑃^∗∗:  two sample 𝑡-test used to determine the significance of Bak expression between each subgroup and the mean of normal tissues. Statistical significance at 𝑃≤0.05.
𝑃^∗∗∗: ANOVA test used to determine the significance of Bak expression among subgroups. The statistical significance was at 𝑃≤0.05.