Evaluation of Bax and Bak Gene Mutations and Expression in Breast Cancer
Table 2
Statistical analysis of the Bax isoforms distribution according to clinical factors.
Factors
Bax α
Bax d
Bax δ
Bax ζ
Number of tissuesa
Number of tissue
%
*
Number of tissue
%
*
Number of tissue
%
*
Number of tissue
%
*
Normal tissue
4
2
50
0.71
3
75
0.6
4
100
0.3
3
75
0.2
0.4
Tumor tissue
20
12
60
17
85
16
80
8
40
0.01
Grade
2
16
8
50
0.6
13
81.3
0.08
14
87.5
0.4
6
37.5
0.3
0.007
3+ high
3
2
66.7
1
33.3
2
66.7
2
66.7
0.7
T stage
T1
3
2
66.7
0.25
2
66.7
0.1
2
66.7
0.2
2
66.7
0.7
1
T2
7
4
57.1
7
100
7
100
2
28.6
0.003
T3
3
—
0
1
33.3
2
66.7
1
33.3
0.4
T4
4
4
66.7
3
50
3
50
2
33.3
0.7
L.N.
N0
6
3
50
0.84
5
83.3
0.8
6
100
0.3
3
50
0.7
0.14
N1
6
4
66.7
5
83.3
5
83.8
3
50
0.5
N2
7
4
57.1
5
71.4
5
71.4
2
28.6
0.3
N3
1
—
0
—
0
—
0
—
0
Histopathology
Invasive duct
17
8
47.1
0.53
12
70.6
0.3
13
76.5
0.3
7
41.2
0.7
0.09
Labular + other
3
2
66.7
3
100
3
100
1
33.3
0.18
ER
Positive
9
5
55.6
0.8
6
66.7
0.5
7
77.8
0.6
3
33.3
1
0.3
Negative
6
3
50
3
50
4
66.7
2
33.3
0.7
PR
Positive
7
3
42.9
0.6
5
71.4
0.6
5
71.4
1
2
28.6
0.5
0.7
Negative
7
4
57.1
4
57.1
5
71.4
3
42.9
0.3
Some cases are omitted because of missing values. : significant distribution of each isoform between the same groups by chi-square test. Statistical significance was at . : significant distribution of the 4 isoforms in each subgroup by chi-square. Statistical significance was at .
