Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

<table>Synthetic pathways for compounds<b> VII–VIII</b>: reagents and conditions: (<b>1</b>) NaNO<sub>2</sub>/HCl/Stirring (75 min); (<b>2</b>) NCCH<sub>2</sub>Y/CH<sub>3</sub>CO<sub>2</sub>NH<sub>4</sub>/EtOH; and (<b>3</b>) N<sub>2</sub>H<sub>4</sub><svg height="5.4499998" id="M9" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 4 5.4499998" width="4" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,5.388)"><path d="M170 255q0 -25 -16 -41t-40 -16t-40 16t-16 41t16 41.5t40 16.5t40 -16.5t16 -41.5z" id="x22C5"></path></g>
</svg>H<sub>2</sub>O.</table>

BioMed Research International

sch3

Scheme 3

Scheme 3: Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents 