Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

Table 2

Effect of compounds Ia, Ic, and Ie on ALT, AST, ALP, and creatinine.

Parameter	Control	Ia	Ic	Ie
ALT (U/L)	22.6 ± 4.6	17.9 ± 2.7	27.16 ± 6.3	20.5 ± 3.1
AST (U/L)	63.4 ± 14.6	69.4 ± 9.5	72 ± 7.8	62.7 ± 9.7
ALP (U/L)	70.6 ± 15	68.5 ± 12.3	63.8 ± 15.4	73.9 ± 13.2
Creatinine (mg/dL)	0.83 ± 0.13	0.8 ± 0.16	0.63 ± 0.09	0.77 ± 0.14