BioMed Research International

Research Article

Gene Expression Correlation for Cancer Diagnosis: A Pilot Study

Table 3

Pair-wise comparisons of the mRNA expression levels of PIK3C3, PIM3, and PTEN during disease progression in eight cancer types with high (), moderate (), and low () correlations were shown as (*), (**), and (***), respectively. Prostate cancer does not contain stage IV samples.


Cancer type	Gene pair	Correlation coefficient ()
Cancer type	Gene pair	Stages 0–IV	Stages 0–III

Breast	PIK3C3-PIM3	0.77 ()*	0.76 ()*
	PIK3C3-PTEN	0.70 ()*	0.77 ()*
	PIM3-PTEN	0.77 ()*	0.79 ()*

Colon	PIK3C3-PIM3	−0.17 ()***	−0.18 ()***
	PIK3C3-PTEN	0.35 ()***	0.41 ()**
	PIM3-PTEN	−0.22 ()***	−0.20 ()***

Kidney	PIK3C3-PIM3	0.52 ()**	−0.30 ()***
	PIK3C3-PTEN	0.40 ()**	−0.25 ()***
	PIM3-PTEN	0.82 ()*	0.56 ()**

Liver	PIK3C3-PIM3	0.49 ()**	0.54 ()**
	PIK3C3-PTEN	0.51 ()**	0.51 ()**
	PIM3-PTEN	0.82 ()*	0.79 ()*

Lung	PIK3C3-PIM3	0.41 ()**	0.52 ()**
	PIK3C3-PTEN	0.44 ()**	0.38 ()**
	PIM3-PTEN	0.21 ()***	0.50 ()**

Ovary	PIK3C3-PIM3	0.65 ()**	0.61 ()**
	PIK3C3-PTEN	0.71 ()*	0.77 ()*
	PIM3-PTEN	0.50 ()**	0.60 ()**

Prostate	PIK3C3-PIM3		0.29 ()***
	PIK3C3-PTEN		−0.23 ()***
	PIM3-PTEN		0.56 ()**

Thyroid	PIK3C3-PIM3	0.47 ()**	0.29 ()***
	PIK3C3-PTEN	0.11 ()***	−0.23 ()***
	PIM3-PTEN	0.75 ()*	0.58 ()**