Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia

Table 1

Mutation status (≥98% homology) and its relationship with IGHV rearrangements and sex.

IGHV family	Mutated cases	Unmutated cases	Mutated and unmutated	%	𝑃	Male/female
IGHV1	2	5	7	3.2	ns	4/3
IGHV1-02	3	7	10	4.6	ns	5/5
IGHV1-03	2	2	4	1.9	ns	0/4
IGHV1-08	3	2	5	2.3	ns	3/2
IGHV1-18	2	2	4	1.9	ns	4/0
IGHV1-46	3	1	4	1.9	ns	3/1
IGHV1-69	3	18	21	9.7	<0.0001	15/6
Total IGHV1	18	37	55	25.5	<0.0001	34/21
IGHV2-01	1	0	1	0.5	ns	0/1
IGHV2-05	0	1	1	0.5	ns	0/1
IGHV2-70	0	1	1	0.5	ns	1/0
Total IGHV2	1	2	3	1.4	ns	1/2
IGHV3	3	2	5	2.3	ns	3/2
IGHV3-07	8	1	9	4.0	ns	9/0
IGHV3-09	2	2	4	1.9	ns	2/2
IGHV3-11	0	5	5	2.3	0.016	4/1
IGHV3-13	1	2	3	1.4	ns	3/0
IGHV3-15	4	2	6	2.8	ns	2/4
IGHV3-20	1	1	2	0.9	ns	1/1
IGHV3-21	6	1	7	3.2	ns	5/2
IGHV3-23	18	1	19	8.8	<0.0001	12/7
IGHV3-30	12	10	22	10.0	ns	17/5
IGHV3-33	4	3	7	3.2	ns	5/2
IGHV3-48	1	2	3	1.4	ns	3/0
IGHV3-49	2	2	4	1.9	ns	1/3
IGHV3-53	1	0	1	0.5	ns	1/0
IGHV3-64	0	1	1	0.5	ns	1/0
IGHV3-72	2	0	2	0.9	ns	2/0
IGHV3-74	7	0	7	3.2	0.018	5/2
Total IGHV3	72	35	107	49.5	0.004	85/22, 𝐏=𝟎.𝟎𝟖𝟖
IGHV4-b	2	2	4	1.9	ns	1/3
IGHV4-04	5	0	5	2.3	0.051	3/2
IGHV4-30	1	1	2	0.9	ns	1/1
IGHV4-31	0	1	1	0.5	ns	1/0
IGHV4-34	14	4	18	8.3	ns	11/7
IGHV4-39	3	3	6	2.8	ns	3/3
IGHV4-59	2	0	2	0.9	ns	1/1
IGHV4-61	3	0	3	1.4	ns	2/1
Total IGHV4	30	11	41	19	0.022	23/18
IGHV5-05	0	1	1	0.5	ns	1/0
IGHV5-51	1	6	7	3.2	0.046	7/0
Total IGHV5	1	7	8	3.7	0.023	8/0, 𝐏=𝟎.𝟎𝟓
IGHV7-04	0	2	2	0.9	ns	0/2
Total IGHV7	0	2	2	0.9	ns	0/2