Network-Assisted Prediction of Potential Drugs for Addiction
Table 2
KEGG pathways significantly enriched with the target genes of addictive drugs.
Pathway name
Number of target genes (%)
Nominal P valuea
Adjusted P valueb
Neuroactive ligand-receptor interaction
56 (61.54)
8.65 × 10−102
7.78 × 10−101
Long-term potentiation
10 (10.99)
3.35 × 10−16
1.51 × 10−15
Calcium signaling pathway
12 (13.19)
3.25 × 10−15
9.75 × 10−15
Amyotrophic lateral sclerosis (ALS)
7 (7.69)
1.94 × 10−11
4.36 × 10−11
Alzheimer's disease
9 (9.89)
8.50 × 10−11
1.53 × 10−10
Tyrosine metabolism
5 (5.49)
2.50 × 10−8
3.75 × 10−8
Drug metabolism-cytochrome P450
5 (5.49)
4.75 × 10−7
6.11 × 10−7
Salivary secretion
5 (5.49)
1.28 × 10−6
1.44 × 10−6
Metabolic pathways
8 (8.79)
2.50 × 10−3
2.50 × 10−3
Nominal P values were calculated using the hypergeometric test.
bAdjusted P values were estimated by Benjamini-Hochberg (1995) multiple testing corrections [17].
