Table 2: KEGG pathways significantly enriched with the target genes of addictive drugs.

Pathway nameNumber of target genes (%)Nominal P valueaAdjusted P valueb

Neuroactive ligand-receptor interaction56 (61.54)8.65 × 10−1027.78 × 10−101
Long-term potentiation10 (10.99)3.35 × 10−161.51 × 10−15
Calcium signaling pathway12 (13.19)3.25 × 10−159.75 × 10−15
Amyotrophic lateral sclerosis (ALS)7 (7.69)1.94 × 10−114.36 × 10−11
Alzheimer's disease9 (9.89)8.50 × 10−111.53 × 10−10
Tyrosine metabolism5 (5.49)2.50 × 10−83.75 × 10−8
Drug metabolism-cytochrome P4505 (5.49)4.75 × 10−76.11 × 10−7
Salivary secretion5 (5.49)1.28 × 10−61.44 × 10−6
Metabolic pathways8 (8.79)2.50 × 10−32.50 × 10−3

Nominal P values were calculated using the hypergeometric test.
bAdjusted P values were estimated by Benjamini-Hochberg (1995) multiple testing corrections [17].