|
| Study | Animal species | Injury model | Main experimental groups | Method/dose of
statin administration | Anesthetic agent | Time of statin administration | Time of outcome measurement | Quality score |
|
| Abrahamson et al., 2009 [24] | Male
mice | CCI | (1) TBI + vehicle ( = 5-6)
(2) TBI + simvastatin ( = 5-6) | Orally,
3 mg/kg/d | Isoflurane | 3 h after injury | 10–14 d after injury | 5 |
|
| Chauhan and Gatto, 2011 [16] | Male C57BL/6J mice | CCI | (1) TBI+ saline ()
(2) TBI + pravastatin ()
(3) TBI + lovastatin ()
(4) TBI + simvastatin () | Orally,
2 mg/kg/d
for 8 weeks | Ketamine | immediately after injury | 7-8 weeks after injury | 3 |
|
| Indraswari et al., 2012 [25] | Male C57BL/6J mice | CCI | (1) TBI + saline ()
(2) TBI + rosuvastatin () | Orally,
1 mg/kg/d
for 5 d | Isoflurane | within 1 h after injury | 31–34 d after injury | 8 |
|
| Lu et al., 2004 [26] | Male
Wistar rats | CCI | (1) TBI + saline ()
(2) TBI + atorvastatin () | Orally,
1 mg/kg/d
for 7 d | Chloral hydrate | 1 d after injury | 1, 4, 8, and 15 d after injury | 7 |
|
| Lu et al., 2007 [13] | Male
Wistar rats | CCI | (1) TBI + saline ()
(2) TBI + atorvastatin ()
and
(1) TBI + saline ()
(2) TBI + atorvastatin ()
(3) TBI + simvastatin () | orally
1 mg/kg/d
for 14 d | Chloral hydrate | 1 d after injury | 11–15 and
31–35 d after injury | 7 |
|
| Wang et al., 2012 [27] | Male
Wistar rats | FPI | (1) TBI + control ()
(2) TBI + atorvastatin () | Orally,
1 mg/kg/d
for 14 d | Chloral hydrate | 1 h after injury | 21–25 d after injury | 5 |
|
| Wang et al., 2007 [28] | Male C57Bl/6J mice | CHI | (1) TBI + vehicle ( = ?)
(2) TBI + simvastatin ( = ?)
(3) TBI + atorvastatin ( = ?) | Subcutaneous injection,
20 mg/kg/d
for 17 d | Isoflurane | Unclear | 21–25 d after injury | 4 |
|
| Wu et al., 2008 [10] | Male
Wistar rats | CCI | (1) TBI + saline ()
(2) TBI + simvastatin () | Orally,
1 mg/kg/d
for 14 d | Chloral hydrate | 1 d after injury | 31–35 d after injury | 7 |
|
| Jin et al., 2013 [29] | Male
Wistar rats | FPI | (1) TBI + saline ()
(2) TBI + atorvastatin () | Orally,
1 mg/kg/d
for 14 d | Chloral hydrate | Within 1 h after injury | 21–25 d after injury | 4 |
|
| Liu, 2009 [30] | Male
Wistar rats | FPI | (1) TBI + saline ()
(2) TBI + simvastatin () | Orally,
20 mg/kg/d,
unclear treatment duration | Chloral hydrate | 1 d after injury | 21–25 d after injury | 5 |
|
| Zhang et al., 2012 [31] | Male
Wistar rats | FPI | (1) TBI + saline ()
(2) TBI + atorvastatin ()
(3) TBI + simvastatin ()
(4) TBI + rosuvastatin () | Orally,
atorvastatin/simvastatin:
2 mg/kg/d for 21 d,
rosuvastatin: 1 mg/kg/d
for 21 d | Chloral hydrate | Within 1 d after injury | 22–28 d after injury | 5 |
|
