The Effects of Gene Polymorphisms in Interleukin-4 and Interleukin-6 on the Susceptibility of Rheumatoid Arthritis in a Chinese Population

Table 3

The genotype and allele frequencies of IL-4 and IL-6 promoter polymorphisms in cases and controls.

	Genotype frequencies (%)			Allele frequencies (%)
C > T, IL-4-590	CC	CT	TT	C	T
Cases (𝑛=752)	481 (63.96)	218 (29.00)	53 (7.05)	1180 (78.46)	324 (21.54)
Controls (𝑛=798)	575 (72.06)	207 (25.94)	16 (2.01)	1357 (85.03)	239 (14.97)
	𝜒^2=27.1515, 𝑃=1.2610×10^−6			𝜒^2=22.4713, 𝑃=2.1330×10^−6, OR = 0.6414
G > C, IL-6-174	GG	GC	CC	G	C
Cases (𝑛=752)	613 (81.52)	124 (16.49)	15 (2.00)	1350 (89.76)	154 (10.24)
Controls (𝑛=798)	786 (98.50)	10 (1.25)	2 (0.25)	1582 (99.12)	14 (0.88)
	𝜒^2=127.0661, 𝑃=2.5582×10^−28			𝜒^2=132.4104, 𝑃=1.2168×10^−30, OR = 0.0776