Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza, Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm
Figure 1
Effect of magnesium lithospermate B (MLB) on endothelial NOS levels (a) and cross section of BAs (b). 10 mg/kg MLB was administered at 1 hr (prevention protocol, P) and 24 hr (treatment protocol, R) after animals were subjected to SAH. BAs eNOS (rt-PCR) was measured. Bottom panels represent micrographs of the cross section of BAs obtained from the healthy controls (A), the SAH only rats (B), the vehicle-treated SAH rats (C), SAH rats received 10 mg/kg/day MLB treatment (D), SAH rats received 10 mg/kg/day, MLB preventive treatment (E), and SAH rats received both 10 mg/kg/day magnesium lithospermate B pretreatment and 1 g L-NAME (F). Standard bar = 200 m. : compared with the vehicle + SAH and MLB prevention group. , comparison between sham and the vehicle + SAH groups. : MLB prevention group compared with the L-NAME treatment group. : compared MLB treatment group with the sham group. Data are mean ± SEM (/group).
