Visual and Anatomical Outcomes of Intravitreal Aflibercept for Treatment-Resistant Neovascular Age-Related Macular Degeneration
Figure 4
Spectral domain OCT over time of a 73-year-old female previously treated with 12 bevacizumab intravitreal injections and 26 ranibizumab injections. (a) OCT image 37 days after the last ranibizumab injection showing a primarily hyporeflective PED with chronic intraretinal cystic changes. Note the complete disruption of the subfoveal IS/OS line. Visual acuity is 42 ETDRS letters (0.26 logMAR). (b) OCT image at month 1, after the first aflibercept injection, shows a fluid free macula and the complete resolution of the PED. Visual acuity is 40 letters (0.30 logMAR). (c) OCT image at month 3, after three aflibercept injections, shows a fluid free macula and trace of a hyperreflective PED. Visual acuity is 41 letters (0.28 logMAR). (d) OCT image at month 6 shows no significant anatomical change as compared with (c). Visual acuity is 45 letters (0.20 logMAR).
