Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis
Figure 3
Fetal intrauterine growth restriction is observed in LDLR KO mice fed with a HC diet. (a) Fetuses retrieved from hypercholesterolemic pregnant females weighed significantly less than fetuses from control mice at the three stages analysed () (E12.5, E15.5, and E18.5, , 24, and 10 fetuses in control females, and , 19, and 31 fetuses in HC-fed females, resp.). (b) Representative picture of a normal fetus obtained from a chow-fed female and one growth restricted fetus obtained from a HC-fed female fixed in Bouin. (c) Fetal weight in E18.5 male and female fetuses from control and HC groups ( to 10 fetuses in each group). Mean ± SEM.
