Administration of the Resveratrol Analogues Isorhapontigenin and Heyneanol-A Protects Mice Hematopoietic Cells against Irradiation Injuries
Figure 3
REV (a), ISOR (b), and HEY-A (c) reduce IR-induced suppression of HPC clonogenic function. Mice BMMNC received treatment with control, REV, ISOR, or HEY-A before being sham-irradiated as a control or sublethally irradiated with 1–4 Gy IR. The clonogenic function of HPCs and BMMNC was analyzed using a CFC assay. Colonies of ≥50 cells were scored under an inverted microscope on day 7 and the results are expressed as the number of CFU-GM per 105 cells. Data are presented as the mean ± SE. * versus control, . REV: resveratrol; ISOR: isorhapontigenin; HEY-A: heyneanol-A; IR: ionizing radiation; HPC: hematopoietic progenitor cell; BMMNC: bone marrow mononuclear cells; CFC: colony-forming cells.
