Research Article

Contribution of Ca2+-Dependent Cl Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

Figure 1

Norepinephrine concentration-response curves obtained in femoral arteries of adult WKY rats (6 months old, (a)), adult SHR (6 months old, (b)), aged WKY rats (12 months old, (c)), and aged SHR (12 months old, (d)) recorded under the control conditions and after the inhibition of NO synthase (L-NNA) or Ca2+-dependent Cl channels blockade (R(+)-IAA-94, IAA) or both (IAA + L-NNA). Data are presented as mean ± S.E.M. (for number of vessels see Table 1). Depicted curves were calculated from average values obtained at studied norepinephrine concentrations.
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(a)
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(b)
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(c)
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(d)