Contribution of Ca²⁺-Dependent Cl⁻ Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

Table 1

Blood pressure and the diameter of isolated femoral arteries in adult and aged Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).

Parameters	Adult WKY (6 months); (𝑛=6)	Aged WKY (12 months); (𝑛=7)	Adult SHR (6 months); (𝑛=6)	Aged SHR (12 months); (𝑛=9)
SBP (mm Hg)	131 ± 3	134 ± 4	221 ± 5^a	215 ± 6^c
MAP (mm Hg)	109 ± 3	112 ± 3	182 ± 5^a	187 ± 4^c
DBP (mmHg)	91 ± 3	94 ± 3	152 ± 4^a	163 ± 4^c
Diameter (𝜇m)	995 ± 21	1052 ± 20^a	843 ± 27^a	943 ± 17^b,c

Data are presented as mean ± S.E.M. SBP: systolic blood pressure; MAP: mean arterial pressure; DBP: diastolic blood pressure. Significant differences: ^a𝑃<0.05 versus adult WKY; ^b𝑃<0.05 versus adult SHR; ^c𝑃<0.05 versus aged WKY.