| | | Iranian family | Sicilian family | Neapolitan family |
| | ID code | I | II | NAPO-16 | NAPO-17 | NAPO-41 | NAPO-42 | | Gender | M | F | M | F | M | F | | Consanguinity | Yes | Yes | Yes | Yes | No | No | | Child developmental milestones | Not available | Normal | Normal | Normal | Delayed | Delayed | | Seizures (age at onset) | Yes (3) | Yes (infancy) | No | No | One episode (uncertain) | One episode (16) | | Age at PD onset | 20 | Early 20s | 22 | 28 | 28 | 26 | | Symptoms at onset | Tremor, bradykinesia | Tremor, bradykinesia, eyelid twitching | Bradykinesia, fatigue, gait impairment, involuntary arm movements | Bradykinesia, speech and gait difficulties, involuntary arm movements | Bradykinesia | Tremor, bradykinesia | | Age at last examination | 29 | 39 | 50 | 34 | 31 | 27 | | Evolution | Eyelid apraxia and dysarthria at 22, generalized bradykinesia, limb rigidity, tremor, hypophonia, postural instability at 29 | Similar to I + needed assistance to walk at 32, bedbound at 37, anarthric state, in fixed posture at 39 | Cognitive decline, severe dysarthria, assistance needed at 23, anarthric state at 25, stooped posture, abnormal gait, axial and limb rigidity, impaired postural reflex, eyelid apraxia, mild dysphagia, dystonia, resting and action tremor at 47, stable at 50 | Stooped posture, abnormal gait, impaired postural reflex, staring gaze at 31, resting and action tremor, axial and limb rigidity, dystonia, dysarthria, hypophonia, mild dysphagia, worsening dystonia and supranuclear gaze palsy at 34 | Hypomimia, impaired speech, mild stooped posture, tremor, axial and limb rigidity, gaze limitation, dystonia, irritability, drooling and dysphagia at 31 | Hypomimia, impaired speech, tremor and limb rigidity, slow gait, reduced postural reflex at 27 | | UPDRS-III score$ (age) | 38 (29) | Not available | 78 (47), 82 (50) | 57 (31), 68 (34) | 42 (31) | 32 (27) | | MMSE$$ (age) | Not available | Not available | Not administered due to severe motor and cognitive disability | 26 (31), 24 (34) | 28 (31) | 24 (27) | | Imaging data | Mild cortical atrophy, bilateral hyperintensity in white matter | Meningioma (surgically removed at 37) | Diffuse cortical atrophy, hyperintensity of hippocampi, thinning midbrain quadrigeminal plate, nigrostriatal dopaminergic deficit, cortical hypometabolism | Diffuse cortical atrophy, hyperintensity of hippocampi, thinning midbrain quadrigeminal plate, cortical hypometabolism | No gross abnormalities, nigrostriatal dopaminergic deficit, mild bilateral hypometabolism | No gross abnormalities, nigrostriatal dopaminergic deficit, mild bilateral hypometabolism | | Response to levodopa | Not tolerated (severe dyskinesia) | Not tolerated (severe dyskinesia) | Not tolerated (dystonia, postural hypotension) | Not tolerated (dystonia, postural hypotension) | Not treated | Not treated |
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