Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis

Table 3

Univariate and multivariate metaregression analyses of potential source of heterogeneity.

Heterogeneity factors	Coefficient	SE			95% CI
					LL	UL
Publication year
Univariate	−0.025	0.023	−1.06	0.288	−0.070	0.021
Multivariate	−0.022	0.025	−0.91	0.361	−0.071	0.026
Ethnicity
Univariate	0.223	0.179	1.25	0.213	−0.127	0.573
Multivariate	0.194	0.224	0.86	0.388	−0.246	0.633
Source of controls
Univariate	−0.199	0.164	−1.21	0.225	−0.521	0.123
Multivariate	−0.116	0.180	−0.65	0.518	−0.468	0.236
Disease
Univariate	−0.113	0.144	−0.79	0.432	−0.396	0.169
Multivariate	−0.006	0.213	−0.03	0.977	−0.425	0.412
Genotyping method
Univariate	−0.199	0.164	−1.21	0.225	−0.521	0.123
Multivariate	−0.023	0.237	−0.10	0.923	−0.487	0.441

SE: standard error, 95% CI: 95% confidence interval, UL: upper limit, and LL: lower limit.