Review Article
Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis
Table 3
Univariate and multivariate metaregression analyses of potential source of heterogeneity.
| Heterogeneity factors | Coefficient | SE | | | 95% CI | LL | UL |
| Publication year | | | | | | | Univariate | −0.025 | 0.023 | −1.06 | 0.288 | −0.070 | 0.021 | Multivariate | −0.022 | 0.025 | −0.91 | 0.361 | −0.071 | 0.026 | Ethnicity | | | | | | | Univariate | 0.223 | 0.179 | 1.25 | 0.213 | −0.127 | 0.573 | Multivariate | 0.194 | 0.224 | 0.86 | 0.388 | −0.246 | 0.633 | Source of controls | | | | | | | Univariate | −0.199 | 0.164 | −1.21 | 0.225 | −0.521 | 0.123 | Multivariate | −0.116 | 0.180 | −0.65 | 0.518 | −0.468 | 0.236 | Disease | | | | | | | Univariate | −0.113 | 0.144 | −0.79 | 0.432 | −0.396 | 0.169 | Multivariate | −0.006 | 0.213 | −0.03 | 0.977 | −0.425 | 0.412 | Genotyping method | | | | | | | Univariate | −0.199 | 0.164 | −1.21 | 0.225 | −0.521 | 0.123 | Multivariate | −0.023 | 0.237 | −0.10 | 0.923 | −0.487 | 0.441 |
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SE: standard error, 95% CI: 95% confidence interval, UL: upper limit, and LL: lower limit.
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