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BioMed Research International
Volume 2014 (2014), Article ID 290878, 9 pages
http://dx.doi.org/10.1155/2014/290878
Research Article

CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation

1Centre de Transplantation Hépatique, Pôle Digestif, APHP, Hôpital Saint Antoine, 184 Rue de Faubourg Saint Antoine, 75012 Paris, France
2UPMC Université Paris 6, Inserm, UMR_S938, Centre de Recherche Saint Antoine, 75012 Paris, France
3UMR 8161, Institut de Biologie de Lille, 1 Rue du Professeur Calmette, 59028 Lille, France
4Unité de Biostatistique, Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Received 30 April 2013; Revised 8 October 2013; Accepted 14 October 2013; Published 19 January 2014

Academic Editor: Kenichi Harada

Copyright © 2014 Stenard Fabien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The TRANSPEG study was a prospective study to assess the efficacy of antiviral therapy in patients with a recurrent hepatitis C virus (HCV) after liver transplantation. The influence of regulatory T-cells (Tregs) on the response to antiviral therapy was analyzed. Patients were considered as a function of their sustained virological response (SVR) at 18 months after treatment initiation. A transcriptomic analysis was performed to assess Treg markers (Tr1 and FoxP3+) in serum, PBMC, and liver biopsies. 100 patients had been included in the TRANSPEG study. Data from 27 of these patients were available. The results showed that the expression of CD49b (a predominant marker of Tr1) before the introduction of antiviral therapy was significantly associated with SVR. Responders displayed lower serum levels of CD49b than nonresponders ( ). These findings were confirmed in PBMC and liver biopsies even if in a nonsignificant manner for the limited number of samples. The assessment of CD49b levels is thus predictive of the response to antiviral therapy. This data suggests that CD49b may be a marker of the failure of the immune response and antiviral therapy during HCV recurrence. The assessment of CD49b could help to select patients who require earlier and more intensive antiviral therapy.