Review Article

Mycobacterium tuberculosis P-Type ATPases: Possible Targets for Drug or Vaccine Development

Table 1

Mtb P-type ATPases and related human counterparts. The search for homologous ATPases was performed using the Blastp tool (http://blast.ncbi.nlm.nih.gov/). The table is organized according to the levels of similarity based on the “scores” from the pairwise alignment obtained using MATCHER (http://mobyle.pasteur.fr).

Mtb P-type ATPaseCloset human homologs
Pairwise alignment score Identifier*Human P-type ATPase

CtpF (Rv1997)1272P98194Ca-transporting ATPase
CtpV (Rv0969)886Q04656Cu-transporting ATPase 1
CtpA (Rv0092)727P35670Cu-transporting ATPase 2
CtpB (Rv0103c)722P35670Cu-transporting ATPase 2
CtpC (Rv3270)539P35670Cu-transporting ATPase 2
CtpI (Rv0107c)450Q13733Na/K-transporting ATPase 4
CtpG (Rv1992c)441P35670Cu-transporting ATPase 2
CtpD (Rv1469)392P35670Cu-transporting ATPase 2
CtpJ (Rv3743c)377Q04656Cu-transporting ATPase 1
CtpH (Rv0425c)334Q93084SERCA Ca ATPase
CtpE (Rv0908)250P98194Ca-transporting ATPase

UniProt identifiers (http://www.uniprot.org/).