Review Article

Mycobacterium tuberculosis P-Type ATPases: Possible Targets for Drug or Vaccine Development

Table 2

Studies investigating M. tuberculosis gene expression profiles under stress conditions.

ModelExperimental conditionsMethodology**References

MDR strains1Comparison between MDR and H37Rv strainsMAChatterjee et al.
(2013) [32]

Toxic substances 
(in vitro)
2SDSRT-qPCR and MAManganelli et al.
(2001) [33]
3Isoniazid, isoxyl, tetrahydrolipstatin, SRI #221, SRI #967, and SRI #9190MAWaddell et al.
(2004) [34]
4Sodium hypochloriteMAJang et al.
(2009) [35]
5Peracetic acidMANde et al.,
(2011) [36]

Toxic substances related to infection  
(in vitro)
6Oxidative stressMAManganelli et al.
(2002) [37]
7Nitrogen reactive substancesRT-qPCR and MAOhno et al.
(2003) [38]
8Physiological levels of copperRT-qPCRWard et al.
(2008) [39]
9Physiological levels of zincRT-qPCR and MABotella et al.
(2011) [11]

Latency  
(in vitro)
10HypoxiaMASherman et al.
(2001) [40]
11HypoxiaMABacon et al.
(2004) [41]
12Hypoxia and nitric oxideMAVoskuil et al.
(2003) [42]
13Steady cultureRT-qPCR and MAKendall et al.
(2004) [43]
14Nonreplicating persistence (NRP)MAMuttucumaru et al.
(2004) [44]
15Nonreplicating persistence (NRP)Proteomic Cho et al.
(2006) [13]
16StarvationMAHampshire et al.
(2004) [45]
17StarvationMABetts et al.
(2002) [46]

Infection  
(in vivo)
18Mouse macrophage infectionMASchnappinger et al.
(2003) [47]
19Mouse lung infection MATalaat et al.
(2004) [31]
20Artificial granulomas in miceMAKarakousis et al.
(2004) [48]
21Human dendritic cells and macrophage infectionMATailleux et al.
(2008) [49]
22Human lung infectionRT-qPCRKumar et al.
(2011) [50]

MA, microarrays.