Natural Compounds and Aging: Between Autophagy and Inflammasome

Table 3

Classification of compounds from food sources associated with anti-NLRP3 inflammasome.

Category	Compounds	Molecular mechanism		Resources	References
Stilbenoids	Resveratrol	Inhibited NLRP3 activation; Induced autophagy	Impaired caspase-1 and IL-1β expression; Reduced the acetylation of cytoplasmic proteins	Veratrum album	[57, 58]
Flavonoids
Flavonols	Quercetin	Suppressed renal NLRP3 activation	Impaired caspase-1 and IL-1β expression	Quercetum	[64, 65]
Flavones	Luteoloside	Inhibited NLRP3 activation	Reduced ROS accumulation; Impaired NLRP3, caspase-1, and IL-1β expression	Honeysuckle	[61]
Flavan-3-ols	Catechins	Inhibited NLRP3 activation; Enhanced autophagy	Impaired caspase-1 and IL-1β expression; Enhanced Beclin 1 expression	Green tea	[37, 38]
	EGCG	Inhibited NLRP3 activation; Enhanced autophagy	Reduced ROS accumulation, NF-κB activation, and NLRP3 expression; Impaired caspase-1 and IL-1β expression	Green tea	[103–105]
Other phenolic compounds	Creosol	Impaired NLRP3 activation	Reduced iNOS expression and NO levels; Decreased ROS production; Impaired IL-1β expression	Bamboo vinegar (BV)	[59]
	Propolis extracts	Inhibited NLRP3 activation	Reduced the IL-1β secretion	Brazilian propolis	[60]

iNOS: inducible nitric oxide synthase; ROS: reactive oxygen species; IL: interleukin; MAPK: mitogen-activated protein kinase; EGCG: epigallocatechin-3-gallate; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells.