High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas

Table 2

Comparison of the mean values of immunological characteristics between patients with tumors positive or negative for HPV (for details see materials and methods).

Immunological characteristics	HPV +	HPV −	𝑃 value	95% CI	𝑃 value adj^a	95% CI adj^a
	Mean	Mean
CD8+ (%)	26.6	26.8	0.896	−3.8; 4.3	0.846	0.9; 1.1
CD4+ (%)	44.3	48.0	0.085	−0.5; 7.9	0.199	0.9; 1.0
CD19+ (%)	11.3	4.7	0.332	−4.4; 1.5	0.305	1.0; 1.2
CD3−CD56+16+ (%)	13.6	6.4	0.005	−7.2; −1.3	0.052	1.0; 1.3
CD4+/CD8+	1.8	2.1	0.355	0.1; 7.8	0.451	0.4; 1.5
Tregs (%)	15.9	15.8	0.998	−4.6; 4.6	0.924	0.9; 1.1
CD8+CD4+sum	70.9	74.8	0.355	0.1; 7.8	0.116	0.9; 1.0
CD8+/Tregs	2.4	3.5	0.258	−0.8; 3.0	0.455	0.7; 1.1

aadjusted for age.
95% CI: confidence interval; 𝑃: probability.