Review Article

Pharmacology of Hallucinations: Several Mechanisms for One Single Symptom?

Table 1

Characteristics of main pictures of hallucinations.

ā€‰Psychostimulants
(cocaine, amphetamine)
Dissociative anesthetics
(PCP, ketamine)
Psychedelics
(LSD, psilocybin)
Schizophrenia
(paranoid)

Supposed pharmacological mode of actionD2R activationNMDAR blockage5HT2AR activationD2R activation/NMDAR blockage
Main type of hallucinationsAuditory Visual Visual Auditory
Most frequent associated delusionsParanoid paranoidMystical Paranoid
Most frequent associated behaviourAgitationSocial withdrawalMystical feelingsVariable
InsightfulnessNo No Yes No