A Novel Homozygous Mutation in the EC1/EC2 Interaction Domain of the Gap Junction Complex Connexon 26 Leads to Profound Hearing Impairment

<table>Alignment of the second extracelluar domain of the connexin 26 protein of various organisms; the identified mutation (c.506G&gt;A, (TGC&gt;TAC), Cys169Tyr) is strongly preserved.</table>

BioMed Research International

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Figure 4

Figure 4: A Novel Homozygous Mutation in the EC1/EC2 Interaction Domain of the Gap Junction Complex Connexon 26 Leads to Profound Hearing Impairment 