Rosiglitazone Increases Cerebral Klotho Expression to Reverse Baroreflex in Type 1-Like Diabetic Rats

Figure 4

Effect of TZD on the sensitivity of the baroreflex in STZ-diabetic rats. The effect on the mean arterial pressure (MAP, mmHg), heart rate (HR, bpm), and baroreflex sensitivity (BRS, bpm/mmHg) in response to phenylephrine (PE, 8 μg/kg, IV) (a) or (SNP, 50 μg/kg, IV) (b) in each group including Wistar rats (Con) and STZ-diabetic rats receiving TZD (STZ + TZD) or not (STZ). The quantification is indicated as the means with the SE (𝑛=8 per group) in each column shown in the lower panel. ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001 compared to control.

(a)

(b)