Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus

<table>Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs. IFN-<i>α</i>/-<i>β</i> binds to their receptors IFNAR-1 and IFNAR-2 on cell membrane, which activates JAK/STAT pathway. “P” besides STAT1 and STAT2 indicates phosphorylation. PRRSV nsp1<i>β</i> inhibits ISGF3 nuclear translocation via inducing degradation of KPNA1, which is essential for mediating the nuclear import of ISGF3. N protein also inhibits ISGF3 nuclear translocation. And nsp2 reduces ISG15 production and conjugation via its deubiquitination activity.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus 