Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
Figure 2
Organelles, such as mitochondria, peroxisome, and ER, dysfunction causes accumulation of reactive oxygen species (ROS) and ER stress in diabetic kidney. Dietary restriction enhances autophagy-lysosomal degradation system, leading to cell or tissue homeostasis. Nutrient-sensing signal and organella maintenance in diabetic nephropathy (DN).