The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment

Table 1

Upregulated apoptosis-associated miRNAs in lung cancer.

MicroRNA	Target genes	Function	Cell lines	In vivo models	Citation
miR-197	BMF, NOXA	Repress p53-dependent apoptotic cascade; miR inhibition decreases cell viability; miR inhibition impairs cell growth and anchorage-independent colony formation	A549, Calu-1, NIH-H460, NCI-H1299	Nude mice	[35]
miR-21	SPRY1, SPRY2, BTG2, PDCD4, APAF1, FasL, RHOB	Enhance tumor proliferation and survival; Inhibit apoptosis; miR deletion suppresses Ras-driven transformation	N/T	K-ras^LA2 mice; CAG-miR-21 transgenic mice; CAG-miR-21; K-ras^LA2 compound mutant mice	[37]
miR-212	AChE	Prevent apoptosis; Maintain cell proliferation capacity; Modulate CDDP-induced NSCLC cell apoptosis	HEK-293T, NCI-H520, NCI-H460,; SK-MES-1,; BEAS-2B	Nude mice	[43]
miR-17-5p, miR-20a	E2F1	miR inhibition reduces of cell growth.; miR inhibition induces apoptosis and increases proportions of sub-G1 populations.	Calu-6, A549,; ACC-LC-172	N/T	[45]

N/D: not determined; N/T: not tested.