The Role of microRNAs in the Regulation of Apoptosis in Lung Cancer and Its Application in Cancer Treatment

Table 3

Drug-associated miRNAs in lung cancer.

Drug	MicroRNA	Target genes	Function	Cell Lines	In vivo models	Citation
Docetaxel	miR-100	Plk1	Chemosensitize lung adenocarcinoma cells to docetaxel; Suppress cell proliferation, enhance apoptosis and cell cycle arrest in the G2/M phase of cell cycle; Down-regulate in vivo cell proliferating ability	SPC-A1, A549,; NCI-H1299,; SPC-A1/DTX	Nude mice	[102]
	miR-650	ING4	Confer docetaxel chemoresistance both in vitro and in vivo	SPC-A1, NCI-H1299	Athymic BALB/c nude mice	[105]
Cisplatin	miR-451	N/D	Enhance DDP chemosensitivity; Inhibit growth and enhance apoptosis	A549	BALB/c nude mice	[84]
	miR-31	ABCB9	Induced DDP resistance; Antiapoptotic effect	SPC-A1, LTEP-A2,; NCI-H460, NCI-H1299	N/T	[86]
Paclitaxel	miR-133a/b, miR-361-3p	N/D	Oncogenic; miR inhibition reduces cell survival	NCI-H1155, NCI-H1993,; NCI-H358	N/T	[91]
	miR-101	EZH2	Decrease proliferation and invasive ability of cells; Sensitize cells to paclitaxel	NCI-H226, A549,; NCI-H358, 801D	N/T	[98]
Gemcitabine	miR-133b	MCL-1,; BCL-W	Increase apoptosis; Gemcitabine sensitivity	A549, NCI-H23,; NCI-H2172, NCI-H226, NCI-H522, NCI-H2009,; NCI-H1703	N/T	[111]
EGFR-TKI	miR-30b/c miR-221/222	APAF-1,; BIM	Gefitinib-induced PARP cleavage; Decrease cell viability; Restore gefitinib sensitivity	Calu-1, A549, PC-9, HCC827	N/T	[123]
	miR-214	PTEN	Oncogenic; Knockdown sensitizes cells to gefitinib	HCC827, HCC827/GR	N/T	[126]
	miR-133b	EGFR	Inhibit cell’s growth and invasion abilities; Enhance EGFR-TKI sensitivity	PC-9, A549, NCI-H1650, NCI-H1975	N/T	[131]
Curcumin	miRNA-186*	Caspase-10	Inhibits cell apoptosis; Down-regulation of miR-186 by curcumin induces apoptosis	A549, A549/DDP	N/T	[154, 157]
TRAIL	miR-221, miR-222	N/D	Impair TRAIL-dependent apoptosis; Induce TRAIL-resistance	Calu-1, A549,; NCI-H460	N/T	[168]
	miR-34a, miR-34c	PDGFR-𝛼, PDGFR-𝛽	Augment TRAIL response; Reduce migratory and invasive capacity of cells	NCI-H460, A549,; NCI-H1299, Calu-6; NCI-H1703,	N/T	[169]
	miR-212	PED	Increase sensitivity to TRAIL; Tumor suppressor	Calu-1, NCI-H460	N/T	[175]
PRIMA-1	miR-34a	N/D	Induce apoptosis in the lung cancer cells containing mutant p53	A549, NCI-H211,; NCI-H1155, NCI-H1299	N/T	[148]
Multidrug Resistance	miR-200bc/429	BCL2, XIAP	Enhanced sensitivity to various anticancer drugs including VCR, CDDP, VP-16, and ADR	A549, A549/CDDP	N/T	[158]
	miR-181b	BCL2	Increased sensitivity to a number of anticancer drugs including VCR, 5-Fu, CDDP, VP-16, and ADR	A549, A549/CDDP	N/T	[161]

N/D: Not determined, N/T: Not tested.